岡山県立大学 保健福祉学部 栄養学科

食品生化学研究室

研究業績

2021

  • Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse
    Izumi Tsukayama, Takuto Mega, Nana Hojo, Keisuke Toda, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto
    Prostaglandins and Other Lipid Mediators, 2021, 156, 106580.
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  • ALOX12 mutation in a family with dominantly inherited bleeding diathesis
    Tetsuo Mitsui, Satoshi Makino, Gen Tamiya, Hiroko Sato, Yuki Kawakami, Yoshitaka Takahashi, Toru Meguro, Hiroko Izumino, Yosuke Sudo, Ikuo Norota, Kuniaki Ishii, Kiyoshi Hayasaka
    Journal of Human Genetics, 2021, 66, 753–759.
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2020

  • Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice
    Yoshiko Mori, Yuki Kawakami, Keita Kanzaki, Akemi Otsuki, Yuka Kimura, Hibiki Kanji, Ryoma Tanaka, Izumi Tsukayama, Nana Hojo, Toshiko Suzuki-Yamamoto, Takayo Kawakami, Yoshitaka Takahashi
    The Journal of Biochemistry, 2020, 168(5), 455-463.
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  • Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation
    Keisuke Toda, Izumi Tsukayama, Yuki Nagasaki, Yuka Konoike, Asako Tamenobu, Natsuki Ganeko, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto
    Archives of Biochemistry and Biophysics, 2020, 689, 108307.
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  • Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis 
    Keisuke Toda, Izumi Tsukayama, Yuki Nagasaki, Yuka Konoike, Asako Tamenobu, Natsuki Ganeko, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto
    Bioscience, Biotechnology, and Biochemistry, 2020, 84(4), 757-763.

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2019

     
  • Involvement of the hydroperoxy group in the irreversible inhibition of leukocyte-type 12-lipoxygenase by monoterpene glycosides contained in the Qing Shan Lu Shui tea
    Yuki Kawakami, Akemi Otsuki, Yoshiko Mori, Keita Kanzaki, Toshiko Suzuki-Yamamoto, Ding Zhi Fang, Hideyuki Ito, Yoshitaka Takahashi
    Molecules, 2019, 24(2), e304.

  • Ingestion of soy protein isolate attenuates eccentric contraction-induced force depression and muscle proteolysis via inhibition of calpain-1 activation in rat fast-twitch skeletal muscle
    Keita Kanzaki, Daiki Watanabe, Chihiro Aibara, Yuki Kawakami, Takashi Yamada, Yoshitaka Takahashi, Masanobu Wada
    Nutrition, 2019, 58, 23-29.

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2018

  • L-arginine ingestion inhibits eccentric contraction-induced proteolysis and force deficit via S-nitrosylation of calpain
    Keita Kanzaki, Daiki Watanabe, Chihiro Aibara, Yuki Kawakami, Takashi Yamada, Yoshitaka Takahashi, Masanobu Wada
    Physiological Reports, 2018, 6(2), e13582.

  • Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway
    Izumi Tsukayama, Keisuke Toda, Yasunori Takeda, Takuto Mega, Mitsuki Tanaka, Yuki Kawakami, Yoshitaka Takahashi, Masumi Kimoto, Kei Yamamoto, Yoshimi Miki, Makoto Murakami, Toshiko Suzuki-Yamamoto
    Journal of Clinical Biochemistry and Nutrition, 2018, 62(2), 139-147.

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2017

  • The Y54(L)W mutation of anti-leukotriene C4 single-chain antibody increases affinity to leukotriene E4
    Yuki Kawakami, Mai Kinoshita, Yoshiko Mori, Shuji Okochi, Shiori Hirano, Ichika Shimoda, Keita Kanzaki, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Mitsuaki Sugahara, Tetsuya Hori, Hiromichi Saino, Masashi Miyano, Shozo Yamamoto, Yoshitaka Takahashi
    The Journal of Biochemistry, 2017, 161(1), 79-86.

  • Comparison of the effects of the 1975 Japanese diet and the modern Mediterranean diet on lipid metabolism in mice
    Yui Mizowaki, Saeko Sugawara, Kazushi Yamamoto, Yu Sakamoto, Yui Iwagaki, Yuki Kawakami, Miki Igarashi, Tsuyoshi Tsuduki
    Journal of Oleo Science, 2017, 66(5), 507-519.

  • 大豆たん白質の摂取により運動後に低下した筋力が早期に回復する機序の解明 (Effect of nitric oxide synthesis inhibition on soy protein diet-induced facilitation of force recovery in muscles undergoing eccentric contractions)
    神崎圭太、渡邊大輝、川上祐生、高橋吉孝、和田正信
    大豆たん白質研究, 2017, 20, 159-164.

 

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2016

  • α-Tocopherol attenuates the triglyceride- and cholesterol-lowering effects of rice bran tocotrienol in rats fed a Western diet
    Akira Shibata, Yuki Kawakami, Toshiyuki Kimura, Teruo Miyazawa, Kiyotaka Nakagawa
    Journal of Agricultural and Food Chemistry, 2016, 64, 5361-5366.

  • The Japanese diet from 1975 delays senescence and prolongs life span in SAMP8 mice
    Kazushi Yamamoto, Shuang E, Yu Hatakeyama, Yu Sakamoto, Taro Honma, Yuri Jibu, Yuki Kawakami, Tsuyoshi Tsuduki
    Nutrition, 2016, 32(1), 122-128.

  • 大豆たん白質に豊富なアミノ酸の摂取は運動後に筋力の低下が継続することを防止するか? (The effect of L-arginine administration on exercise-induced calpain activation and force depression)
    神崎圭太、渡邊大輝、川上祐生、高橋吉孝、和田正信
    大豆たん白質研究, 2016, 19, 136-142.

 

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2015

  • Inhibition of leukocyte-type 12-lipoxygenase by guava tea leaves prevents development of atherosclerosis
    Yoshitaka Takahashi, Akemi Otsuki, Yoshiko Mori, Yuki Kawakami, Hideyuki Ito
    Food Chemistry, 2015, 186, 2-5.

  • シクロオキシゲナーゼ阻害効果をもつ大豆イソフラボンのがん細胞増殖への影響 (Antiproliferative activity of genistein via inhibition of cyclooxygenases)
    川上祐生、高橋吉孝
    大豆たん白質研究, 2015, 18, 221-225.

  • 高校生を対象とした分子生物学実験に関する報告-高校生のための大学授業開放2015- (A report on molecular biological experiment for high school students at Okayama Prefectural University in 2015)
    津嘉山泉、武田泰典、川上祐生、山本登志子
    岡山県立大学保健福祉学部紀要, 2015, 22, 203-209.

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2014

  • Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies
    Yuki Kawakami, Shiori Hirano, Mai Kinoshita, Akemi Otsuki, Toshiko Suzuki-Yamamoto, Makiko Suzuki, Masumi Kimoto, Sae Sasabe, Mitsuo Fukushima, Koji Kishimoto, Takashi Izumi, Toru Oga, Shuh Narumiya, Mitsuaki Sugahara, Masashi Miyano, Shozo Yamamoto, Yoshitaka Takahashi
    Biochimica et Biophysica Acta - General Subjects, 2014, 1840(6), 1625-1633.

  • Effects of isoflavone supplementation on disturbances in lipid metabolism and antioxidant system due to exogenous cholesterol oxidation products in rats
    Yuki Kawakami, Tomoko Kiyosawa, Shingo Nakamura, Kyoichi Osada
    Journal of Functional Foods, 2014, 7, 212-218.

  • Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells
    Toshiko Suzuki-Yamamoto, Sayuri Tanaka, Izumi Tsukayama, Miki Takafuji, Takae Hanada, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi
    Journal of Clinical Biochemistry and Nutrition, 2014, 55, 162-167.

  • 時代と共に変化した日本食が母乳を介して仔マウスの脂質代謝系に与える影響 (Effects of Japanese food typical of that consumed during different periods in the past on breast milk-mediated lipid metabolism in offspring)
    畠山雄有、北野泰奈、本間太郎、卾爽、山本和史、治部祐里、川上祐生、都築毅
    日本栄養・食糧学会誌, 2014, 67(5), 255-270.

  • 時代とともに変化した日本食がマウスの肥満発症リスクに与える影響(Effects of historical differences in components of the Japanese diet on the risk of obesity in mice)
    北野泰奈、本間太郎、畠山雄有、治部祐里、川上祐生、都築毅、仲川清隆、宮澤陽夫
    日本栄養・食糧学会誌, 2014, 67(2), 73-85.

 

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2013

  • Two new monoterpene glycosides with inhibitory effects on leukocyte-type 12-lipoxygenase activity from Qing Shan Lu Shui tea
    Hideyuki Ito, Akemi Otsuki, Hitomi Mori, Peng Li, Mai Kinoshita, Yuki Kawakami, Hideaki Tsuji, Ding Zhi Fang, Yoshitaka Takahashi
    Molecules, 2013, 18, 4257-4266.

  • 生理活性脂質合成系をターゲットとした自然薯粉含有食の食品機能性の解析 (Food functionality of the diet containing Dioscorea japonica powder targeting bioactive lipid synthesis pathway)
    山本登志子、田中小百合、津嘉山泉、大本安梨紗、吉尾壯兒、川上祐生、木本眞順美、高橋吉孝
    岡山県立大学保健福祉学部紀要, 2013, 20, 37-44.

  • 年代別日本食の健康有益性比較: 脂質・糖代謝系に焦点を当てた検討 (Comparison of the health benefits of different eras of Japanese foods: lipid and carbohydrate metabolism focused research)
    本間太郎、北野泰奈、木島遼、治部祐里、川上祐生、都築毅、仲川清隆、宮澤陽夫
    日本食品科学工学会誌, 2013, 60(10), 541-553.

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2012

  • Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity
    Yuki Kawakami, Tomoko Hosokawa, Tomoko Morinaka, Shioka Irino, Shiori Hirano, Hirokaza Kobayashi, Akiko Yoshioka, Toshiko Suzuki-Yamamoto, Miyuki Yokoro, Masumi Kimoto, Hideaki Tsuji, Hiromi Yamashita, Shinobu Doi, Chikao Yutani, Rina Kato, Hiroyuki Itabe, Teruyuki Kanada, Takahiko Hada, Yoshitaka Takahashi
    Food Chemistry, 2012, 131(4), 1069-1075.

  • Physiological effects and tissue distribution from large doses of tocotrienol in rats
    Akira Shibata, Kiyotaka Nakagawa, H. Shirakawa, Teiko Kobayashi, Yuki Kawakami, Rie Takashima, Ai Ohashi, Shoko Sato, Yusuke Ohsaki, Fumiko Kimura, Toshiyuki Kimura, Tsuyoshi Tsuduki, Michio Komai, Teruo Miyazawa
    Bioscience, Biotechnology, and Biochemistry, 2012, 76(9), 1805-1808.

  • 日本人の共役リノール酸摂取量に関する考察 (Consideration about the intake of conjugated linoleic acid in the Japanese)
    本間太郎、佐藤謙太、篠原菜穂子、伊藤隼哉、荒井達也、木島遼、菅原草子、治部祐里、川上祐生、野坂直久、青山敏明、都築毅、池田郁男
    日本食品科学工学会誌, 2012, 59(2), 63-68.

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2011

  • Expression of a single-chain antibody that neutralizes the effect of cysteinyl leukotrienes
    Yoshitaka Takahashi, Yuki Kawakami, Shiori Hirano, Mai Kinoshita, Akemi Otsuki, Toshiko Suzuki-Yamamoto, Yuko Kurahashi, Hiromi Daiyasu, Hiroyuki Toh, Koji Kishimoto, Takashi Izumi, Shozo Yamamoto
    Chemistry and Physics of Lipids, 2011, 164, Supplement, S25.

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2010

  • Functional expression of single-chain antibody to leukotriene C4
    Yuki Kawakami, Chiaki Yamashita, Yoshiko Kashiwase, Tomoko Morinaka, Toshiko Suzuki-Yamamoto, Hiromi Yamashita, Masumi Kimoto, Hideaki Tsuji, Yuko Kurahashi, Hiromi Daiyasu, Hiroyuki Toh, Mitsuaki Sugahara, Masashi Miyano, Shozo Yamamoto, Yoshitaka Takahashi
    Biochemical and Biophysical Research Communications, 2010, 392(3), 421-425.

  • 大豆イソフラボンのシクロオキシゲナーゼ活性調節作用に関する研究 (Effect of soy isoflavones on cyclooxygenase activity)
    川上祐生、高橋吉孝
    大豆たん白質研究, 2010, 13, 181-185.

  • Suppression of γ-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling
    Akira Shibata, Kiyotaka Nakagawa, Yuki Kawakami, Tsuyoshi Tsuduki, Teruo Miyazawa
    Journal of Agricultural and Food Chemistry, 2010, 58(11), 7013-7020.

  • トコトリエノールによるHaCaT皮膚角化細胞とヘアレスマウス皮膚の紫外線炎症反応の抑制
    柴田央、仲川清隆、川上祐生、都築毅、宮澤陽夫
    ビタミン, 2010, 84(8), 383-385.

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2009

  • Tumor-suppressive lipoxygenases inhibit expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells
    Yuki Kawakami, Noriyuki Kubota, N. Ekuni, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Hiromi Yamashita, Hideaki Tsuji, Tanihiro Yoshimoto, Mitsuo Jisaka, Junko Tanaka, Hirofumi F Fujimura, Yoshihiro Miwa, Yoshitaka Takahashi
    Bioscience, Biotechnology, and Biochemistry, 2009, 73(8), 1811-1817.

  • Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms
    Yuki Kawakami, Tomomi Nakamura, Tomoko Hosokawa, Toshiko Suzuki-Yamamoto, Hiromi Yamashita, Masumi Kimoto, Hideaki Tsuji, Hideki Yoshida, Takahiko Hada, Yoshitaka Takahashi
    Prostaglandins, Leukotrienes and Essential Fatty Acids, 2009, 80, 239-245.

  • Anti-angiogenic and anti-cancer potential of unsaturated vitamin E, tocotrienol
    Teruo Miyazawa, Akira Shibata, Phumon Sookwong, Yuki Kawakami, Takahiro Eitsuka, Akira Asai, Shinichi Oikawa, Kiyotaka Nakagawa
    Journal of Nutritional Biochemistry, 2009, 20(2), 79-86.

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2008

  • Tumor angiogenesis suppression by conjugated linoleic acid
    Tsuyoshi Tsuzuki, Yuki Kawakami
    Journal of Clinical Biochemistry and Nutrition, 2008, 43(suppl. 1), 164-167.

  • Tumor angiogenesis suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via peroxisome proliferator-activated receptor γ
    Tsuyoshi Tsuzuki, Yuki Kawakami
    Carcinogenesis, 2008, 29(4) 797-806.

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2007

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2006

  • γ-Tocopherol, but not α-tocopherol, potently inhibits neointimal formation induced by vascular injury in insulin resistant rats
    Katsuaki Takahashi, Tatsuya Komaru, Satoru Takeda, Morihiko Takeda, Ryoji Koshida, Masaharu Nakayama, Yasunori Kokusho, Yuki Kawakami, Nobuhiro Yamaguchi, Teruo Miyazawa, Hiroaki Shimokawa, Kunio Shirato
    Journal of Molecular and Cellular Cardiology, 2006, 41(3), 544-554.

  • Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid
    Tsuyoshi Tsuzuki, Yuki Kawakami, Renpei Abe, Kiyotaka Nakagawa, Kazunori Koba, Jun Imamura, Toshio Iwata, Ikuo Ikeda, Teruo Miyazawa
    Journal of Nutrition, 2006, 136(8), 2153-2159.

  • Conjugated docosahexaenoic acid inhibits lipid accumulation in rats
    Tsuyoshi Tsuzuki, Yuki Kawakami, Kiyotaka Nakagawa, Teruo Miyazawa
    Journal of Nutritional Biochemistry, 2006, 17(8), 518-524.

  • Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol
    Kyoichi Osada, Takashi Suzuki, Yuki Kawakami, Mineo Senda, Atsushi Kasai, Manabu Sami, Yutaka Ohta, Tomomasa Kanda, Mitsuo Ikeda
    Lipids, 2006, 41(2), 133-139.

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2005

  • Comparison of regulative functions between dietary soy isoflavones aglycone and glucoside on lipid metabolism in rats fed cholesterol
    Yuki Kawakami, Wakako Tsurugasaki, Shingo Nakamura, Kyoichi Osada
    Journal of Nutritional Biochemistry, 2005, 16(4), 205-212.

  • Intake of conjugated eicosapentaenoic acid suppresses lipid accumulation in liver and epididymal adipose tissue in rats
    Tsuyoshi Tsuzuki, Yuki Kawakami, Yoshihiro Suzuki, Renpei Abe, Kiyotaka Nakagawa, Teruo Miyazawa
    Lipids, 2005, 40(11), 1117-1123.

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2004

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2003

  • 大豆イソフラボン-アグリコン摂取による脂質代謝調節および抗酸化機能の追究:性別による調節作用の違い (Function of lipid metabolism and antioxidative activity of dietary soybean isoflavone aglycone: differences in regulative function between male and female rats)
    長田恭一、川上祐生、清澤朋子
    大豆たん白質研究, 2003, 6, 108-115.

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2002

  • 加齢に伴う脂質代謝変動と抗酸化体制の低下に対する大豆イソフラボン摂取による改善効果の追究 (Preventive effects of dietary isoflavone on age-associated modulation of lipid metabolism and antioxidative system in rats)
    長田恭一、鶴ヶ崎和華子、川上祐生、中村信吾
    大豆たん白質研究, 2002, 5, 122-128.

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